CarsonScience.com I am a medical school professor, research scientist, consultant, inventor, and amateur photographer. I teach, do research, and provide professional service in the Department of Pathology and Microbiology at The University of Nebraska Medical Center. Consulting and business activities not associated with the university are done through IRBF Development, LLC.

 

Research and Teaching

 

Research

I enjoy work in the lab, and I continue to do what I enjoy. I remain interested in blood coagulation, which I studied for over 20 years, but my current research is focused on group B coxsackieviruses and their receptor (Carson, Chapman, and Tracy, 1997; Carson, Chapman, Hafenstein, and Tracy, 2011). The group B coxsackieviruses can cause serious infections of the heart (myocarditis), pancreas (pancreatitis, and possibly diabetes), and brain (encephalitis), and can be particularly dangerous in babies. My current research investigates molecules that bind group B coxsackieviruses, their effects on virus viability/stability, and how they alter the interaction of the viruses with the CAR (coxsackievirus and adenovirus receptor) and with cells (Organtini et al, 2014; Carson, 2014). I am increasingly curious about selective pressures that drive these viruses to bind molecules other than the CAR (Carson, Chapman, Hafenstein, and Tracy, 2011), and mechanisms that affect virus stability and efficiency for infecting target cells (Carson et al, 2016).

 

Teaching

Through 2019, Dr. Sam Pirruccello and I coordinated four hours of lectures in the Hematology section of the second year curriculum, or more recently, the Blood Organ Core of the first year medical curriculum. I taught the fundamental biochemistry of blood coagulation, fibrinolysis, and their regulation. This introduced the students to platelets, enzymes, cofactors, inhibitors, and other proteins that participate in hemostasis, and the basic principles involved in regulation (e.g. activation, feedback loops, inhibition). This prepared them with the vocabulary and concepts necessary to appreciate Dr. Pirruccello's lectures on clinical bleeding and clinical thrombosis. I have now refocused my efforts on research, and Dr. Scott Koeppsel has taken on the introductory coagulation lectures.

In the Graduate College, Dr. Maurice Godfrey and I teamed together to teach Molecular Basis of Disease. This was a three-credit upper-level graduate course concentrating on human biochemical genetics. Dr. Lois Starr, a clinical geneticist, was a co-director of the course as of 2016. Her clinical expertise provided a new dimension to the course. Following a brief review of genetic principles, well-studied inborn errors of metabolism and development were used to illustrate how genetic variations (e.g. mutations) alter metabolic, developmental, or signaling systems and result in the expressed phenotype. Disease processes were considered in the context of environment and genetic diversity. One-third of the course involved discussion of contemporary literature relevant to diseases for which mechanisms are not yet well understood or only recently elucidated. This required the graduate students to learn on their own behalf prior to the discussion. I have now focused my effort on my research as I approach retirement. The course will be offered in the future under the direction of Dr. Javeed Iqbal.

Other involvement in graduate education includes past decades of service on the Pathology and Microbiology Graduate Committee, and participation on student supervisory committees.

Instructional and Informational Pages:

Calculate TCID50/mL
PAMM 940 Molecular Basis of Disease
Group B Coxsackievirus Capsids -- Lab mutants
Wall Quotes
Cost of Writing Grant Proposals
Monoclonal antibodies against CAR (coxsackievirus and adenovirus receptor)
Continuous chromogenic rate assay for Tissue Factor, Factor VII, or Factor X
Web Presentations adapted from PowerPoint
Basics of Enzyme Kinetics from Dr. J. Jesty PDF

 

 

 

 

 

 

 

 

 

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